Diamondbacks vs. Cardinals Prediction: St. Louis Predicted to Win Sunday's MLB Matchup [5/25/2025]

The St. Louis Cardinals and Arizona dbacks are scheduled to meet in MLB action at Busch Stadium on Sunday, starting at 2:15PM ET.

The Cardinals will have Sonny Gray (5-1, 4.02 ERA) as their starting pitcher, up against Brandon Pfaadt (7-3, 3.81 ERA) for the Diamondbacks.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Arizona-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 54%, while the Diamondbacks have 46%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cardinals predictions page.

Cardinals vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB matchup between the Diamondbacks and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cardinals a 54% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 65% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Diamondbacks vs. Cardinals Odds [5/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Cardinals
Run Line	+1.5 (-205)	-1.5 (+170)
Moneyline	+110	-125
Total	o7.5 (+104)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Cardinals Game-Day Updates and Essential Details

Sunday's MLB game between the Cardinals and Diamondbacks at Busch Stadium is scheduled to start at 2:15PM ET.

• Who: Arizona Diamondbacks vs. St. Louis Cardinals
• Date: Sunday, May 25, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Sunday's Diamondbacks vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 54% win probability, will likely beat the Diamondbacks on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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