Diamondbacks vs. Cardinals Prediction: St. Louis Predicted to Win Saturday's MLB Matchup [5/24/2025]

The St. Louis Cardinals and Arizona dbacks will meet in MLB action at Busch Stadium on Saturday, starting at 2:15PM ET.

The Cardinals will start Matthew Liberatore (3-3, 2.92 ERA), while the Diamondbacks will counter with Merrill Kelly (5-2, 3.26 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Arizona-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cardinals are more likely to win, while the Diamondbacks have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cardinals predictions page.

Cardinals vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the Diamondbacks and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 53% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Diamondbacks vs. Cardinals Odds [5/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Cardinals
Run Line	+1.5 (-225)	-1.5 (+170)
Moneyline	+105	-115
Total	o7.5 (-105)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Diamondbacks vs. Cardinals Game-Day Updates and Essential Details

Saturday's MLB matchup between the Cardinals and Diamondbacks at Busch Stadium is scheduled to start at 2:15PM ET.

• Who: Arizona Diamondbacks vs. St. Louis Cardinals
• Date: Saturday, May 24, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Saturday's Diamondbacks vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cardinals, with a 53% win probability, will likely beat the Diamondbacks on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.