Diamondbacks vs. Cardinals Prediction: Arizona Predicted to Win Friday's MLB Matchup [5/23/2025]

The St. Louis Cardinals and Arizona dbacks are scheduled to meet in MLB action at Busch Stadium on Friday, starting at 8:15PM ET.

Miles Mikolas (3-2, 3.77 ERA) will start on the mound for the Cardinals, while the Diamondbacks have opted for Zac Gallen (3-5, 5.14 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Arizona-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Diamondbacks' chance of winning is 52%, while the Cardinals' is 48%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Cardinals predictions page.

Cardinals vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Diamondbacks and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 52% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 8 runs has a 54% chance of going over.

Diamondbacks vs. Cardinals Odds [5/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Cardinals
Run Line	-1.5 (+152)	+1.5 (-175)
Moneyline	-112	-104
Total	o8 (-114)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Diamondbacks vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB matchup between the Cardinals and Diamondbacks at Busch Stadium is scheduled to commence at 8:15PM ET.

• Who: Arizona Diamondbacks vs. St. Louis Cardinals
• Date: Friday, May 23, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Friday's Diamondbacks vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 52% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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