Diamondbacks vs. Giants Prediction: Arizona Predicted to Win Wednesday's MLB Matchup [5/14/2025]

The San Francisco Giants will square off with the Arizona Diamondbacks in MLB action at Oracle Park on Wednesday, starting at 3:45PM ET.

Jordan Hicks (1-4, 5.82 ERA) will be the starting pitcher for the Giants, pitting him against Eduardo Rodriguez (1-3, 6.86 ERA) for the Diamondbacks.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Arizona-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 51%, with the Giants at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Giants predictions page.

Giants vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Diamondbacks and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Diamondbacks a 51% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 55% chance of staying under.

Diamondbacks vs. Giants Odds [5/14/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Giants
Run Line	-1.5 (+150)	+1.5 (-170)
Moneyline	-115	-102
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Giants Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Giants matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Giants Game-Day Updates and Essential Details

Wednesday's MLB action between the Giants and Diamondbacks at Oracle Park is scheduled to commence at 3:45PM ET.

• Who: Arizona Diamondbacks vs. San Francisco Giants
• Date: Wednesday, May 14, 2025
• Time: 3:45PM ET/12:45PM PT
• Venue: Oracle Park

Dimers.com's comprehensive preview of Wednesday's Diamondbacks vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 51% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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