Diamondbacks vs. Giants prediction: San Francisco favored to win Wednesday's MLB matchup [9/10/2025]

MLB action continues on Wednesday at 3:45PM ET as the Arizona Diamondbacks lock horns with the San Francisco Giants at Oracle Park.

The Giants will have Carson Seymour (1-2, 4.25 ERA) as their starting pitcher, pitting him against Eduardo Rodriguez (7-8, 5.22 ERA) for the Diamondbacks.

Based on the latest simulations, Dimers' proven MLB model projects the Giants as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Diamondbacks-Giants game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Giants' chance of winning at 54%, with the Diamondbacks at 46%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Giants predictions page.

Giants vs. Diamondbacks prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Diamondbacks and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Giants a 54% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 65% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.

Diamondbacks vs. Giants odds [9/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Giants
Run Line	+1.5 (-200)	-1.5 (+164)
Moneyline	+110	-125
Total	o8.5 (-122)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Giants picks and best bets

Our model's biggest edge in today's Diamondbacks vs. Giants matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Diamondbacks vs. Giants game-day updates and essential details

Wednesday's MLB action between the Giants and Diamondbacks at Oracle Park is scheduled to start at 3:45PM ET.

• Who: Arizona Diamondbacks vs. San Francisco Giants
• Date: Wednesday, September 10, 2025
• Time: 3:45PM ET/12:45PM PT
• Venue: Oracle Park

Dimers' full preview of Wednesday's Diamondbacks vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 54% win probability, will likely beat the Diamondbacks on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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