Diamondbacks vs. Giants prediction: San Francisco favored to win Monday's MLB matchup [9/8/2025]

The San Francisco Giants and Arizona dbacks will lock horns in MLB action at Oracle Park on Monday, starting at 9:45PM ET.

Logan Webb (13-9, 3.17 ERA) will be the starting pitcher for the Giants, while the Diamondbacks have opted for Nabil Crismatt (2-0, 2.14 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Giants as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Giants predictions page.

Giants vs. Diamondbacks prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Diamondbacks and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Giants a 62% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 57% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

Diamondbacks vs. Giants odds [9/8/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Giants
Run Line	+1.5 (-135)	-1.5 (+119)
Moneyline	+156	-174
Total	o7.5 (-118)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Giants picks and best bets

Our model's biggest edge in today's Diamondbacks vs. Giants matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Diamondbacks vs. Giants game-day updates and essential details

Monday's MLB action between the Giants and Diamondbacks at Oracle Park is scheduled to begin at 9:45PM ET.

• Who: Arizona Diamondbacks vs. San Francisco Giants
• Date: Monday, September 8, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers' in-depth preview of Monday's Diamondbacks vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 62% win probability, will likely beat the Diamondbacks on Monday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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