Diamondbacks vs. Padres prediction: San Diego favored to win Sunday's MLB matchup [9/28/2025]

The San Diego Padres and Arizona dbacks are scheduled to meet in MLB action at PETCO Park on Sunday, starting at 3:10PM ET.

The Padres will have JP Sears (8-11, 5.12 ERA) as their starting pitcher, while the Diamondbacks are going with Brandon Pfaadt (13-8, 5.00 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Diamondbacks-Padres game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 55%, while the Diamondbacks have 45%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Padres predictions page.

Padres vs. Diamondbacks prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB matchup between the Diamondbacks and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 55% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 64% chance of covering the run line, while the over/under total of 8 runs has a 61% chance of going over.

Diamondbacks vs. Padres odds [9/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Padres
Run Line	+1.5 (-184)	-1.5 (+165)
Moneyline	+117	-134
Total	o8 (-105)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Padres picks and best bets

Our model's strongest edge in today's Diamondbacks vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Diamondbacks vs. Padres game-day updates and essential details

Sunday's MLB action between the Padres and Diamondbacks at PETCO Park is scheduled to begin at 3:10PM ET.

• Who: Arizona Diamondbacks vs. San Diego Padres
• Date: Sunday, September 28, 2025
• Time: 3:10PM ET/12:10PM PT
• Venue: PETCO Park

Dimers' full preview of Sunday's Diamondbacks vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 55% win probability, will likely beat the Diamondbacks on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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