Diamondbacks vs. Padres prediction: San Diego favored to win Saturday's MLB matchup [9/27/2025]

MLB action continues on Saturday at 8:40PM ET as the Arizona Diamondbacks lock horns with the San Diego Padres at PETCO Park.

Michael King (5-3, 3.57 ERA) will get the ball for the Padres, while the Diamondbacks have opted for Eduardo Rodriguez (9-8, 4.92 ERA).

Based on the latest simulations, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Padres predictions page.

Padres vs. Diamondbacks prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Diamondbacks and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 58% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 58% chance of going over.

Diamondbacks vs. Padres odds [9/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Padres
Run Line	+1.5 (-164)	-1.5 (+145)
Moneyline	+135	-154
Total	o7.5 (-104)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Padres picks and best bets

Our model's strongest edge in today's Diamondbacks vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Diamondbacks vs. Padres game-day updates and essential details

Saturday's MLB game between the Padres and Diamondbacks at PETCO Park is scheduled to begin at 8:40PM ET.

• Who: Arizona Diamondbacks vs. San Diego Padres
• Date: Saturday, September 27, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: PETCO Park

Dimers' comprehensive preview of Saturday's Diamondbacks vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 58% win probability, will likely beat the Diamondbacks on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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