Diamondbacks vs. Padres prediction: San Diego favored to win Friday's MLB matchup [9/26/2025]

The San Diego Padres and Arizona dbacks are scheduled to meet in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

The Padres will have Yu Darvish (4-5, 5.51 ERA) as their starting pitcher, while the Diamondbacks have opted for Zac Gallen (13-14, 4.70 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Padres predictions page.

Padres vs. Diamondbacks prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Friday's MLB matchup between the Diamondbacks and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 57% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 61% chance of going over.

Diamondbacks vs. Padres odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Padres
Run Line	+1.5 (-181)	-1.5 (+164)
Moneyline	+123	-126
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Padres picks and best bets

Our model's strongest edge in today's Diamondbacks vs. Padres matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Padres game-day updates and essential details

Friday's MLB action between the Padres and Diamondbacks at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Arizona Diamondbacks vs. San Diego Padres
• Date: Friday, September 26, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' comprehensive preview of Friday's Diamondbacks vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 57% win probability, will likely beat the Diamondbacks on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.