Diamondbacks vs. Pirates Prediction: Arizona Predicted to Win Saturday's MLB Matchup [7/26/2025]

The Pittsburgh Pirates and Arizona dbacks will lock horns in MLB action at PNC Park on Saturday, starting at 6:40PM ET.

Andrew Heaney (4-9, 5.03 ERA) will be the starting pitcher for the Pirates, up against Merrill Kelly (9-5, 3.32 ERA) for the Diamondbacks.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Pirates predictions page.

Pirates vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Diamondbacks and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Diamondbacks a 54% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the 9-run over/under has a 54% chance of staying under.

Diamondbacks vs. Pirates Odds [7/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Pirates
Run Line	-1.5 (+115)	+1.5 (-135)
Moneyline	-144	+125
Total	o9 (-108)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Pirates matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Diamondbacks vs. Pirates Game-Day Updates and Essential Details

Saturday's MLB matchup between the Pirates and Diamondbacks at PNC Park is scheduled to commence at 6:40PM ET.

• Who: Arizona Diamondbacks vs. Pittsburgh Pirates
• Date: Saturday, July 26, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Saturday's Diamondbacks vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 54% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate predictions for the World Series, American League, National League and each division.