Diamondbacks vs. Pirates Prediction: Pittsburgh Predicted to Win Friday's MLB Matchup [7/25/2025]

The Pittsburgh Pirates will take on the Arizona Diamondbacks, in what is expected to be a tight MLB game, at PNC Park on Friday, commencing at 6:40PM ET.

Mike Burrows (1-3, 4.70 ERA) will be the starting pitcher for the Pirates, while the Diamondbacks have opted for Ryne Nelson (6-2, 3.52 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Pirates predictions page.

Pirates vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Diamondbacks and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Pirates a 51% chance of beating the Diamondbacks.

According to our model, the Pirates (+1.5) have a 64% chance of covering the run line, while the 9-run over/under has a 53% chance of staying under.

Diamondbacks vs. Pirates Odds [7/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Pirates
Run Line	-1.5 (+145)	+1.5 (-172)
Moneyline	-113	-102
Total	o9 (-102)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Pirates matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Pirates Game-Day Updates and Essential Details

Friday's MLB matchup between the Pirates and Diamondbacks at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Arizona Diamondbacks vs. Pittsburgh Pirates
• Date: Friday, July 25, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Friday's Diamondbacks vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Pirates, with a 51% win probability, will likely beat the Diamondbacks on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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