Diamondbacks vs. Twins prediction: Why Minnesota is favored to win Saturday's MLB matchup [9/13/2025]

The Minnesota Twins will face the Arizona Diamondbacks in MLB action at Target Field on Saturday, starting at 7:10PM ET.

Joe Ryan (13-8, 3.32 ERA) will start for the Twins, while the Diamondbacks have opted for Ryne Nelson (7-3, 3.48 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Twins as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Twins predictions page.

Twins vs. Diamondbacks prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Diamondbacks and Twins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Twins a 57% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Diamondbacks vs. Twins odds [9/13/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Twins
Run Line	+1.5 (-184)	-1.5 (+152)
Moneyline	+116	-134
Total	o8.5 (-105)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Diamondbacks vs. Twins picks and best bets

Our model's strongest edge in today's Diamondbacks vs. Twins matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Diamondbacks vs. Twins game-day updates and essential details

Saturday's MLB matchup between the Twins and Diamondbacks at Target Field is scheduled to start at 7:10PM ET.

• Who: Arizona Diamondbacks vs. Minnesota Twins
• Date: Saturday, September 13, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Target Field

Dimers' in-depth preview of Saturday's Diamondbacks vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Maryland sports fans

To make the most of Saturday's mammoth day of sports, headlined by college football Saturday games, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Twins, with a 57% win probability, will likely beat the Diamondbacks on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest predictions for the World Series, American League, National League and each division.