Diamondbacks vs. Twins prediction: Why Minnesota is favored to win Friday's MLB matchup [9/12/2025]

The Minnesota Twins will take on the Arizona Diamondbacks in MLB action at Target Field on Friday, beginning at 8:10PM ET.

The Twins will send Pablo López (5-4, 2.84 ERA) to the mound, pitting him against Brandon Pfaadt (13-8, 5.18 ERA) for the Diamondbacks.

Based on the latest simulations, Dimers' proven MLB model projects the Twins as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Twins predictions page.

Twins vs. Diamondbacks prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Diamondbacks and Twins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Twins a 58% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Diamondbacks vs. Twins odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Twins
Run Line	+1.5 (-176)	-1.5 (+155)
Moneyline	+122	-142
Total	o8.5 (-102)	u8.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Twins picks and best bets

Our model's strongest edge in today's Diamondbacks vs. Twins matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Twins game-day updates and essential details

Friday's MLB game between the Twins and Diamondbacks at Target Field is scheduled to start at 8:10PM ET.

• Who: Arizona Diamondbacks vs. Minnesota Twins
• Date: Friday, September 12, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Target Field

Dimers' in-depth preview of Friday's Diamondbacks vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Twins, with a 58% win probability, will likely beat the Diamondbacks on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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