Diamondbacks vs. Dodgers Prediction: Dodgers Predicted to Win Wednesday's MLB Matchup [5/21/2025]

The Los Angeles Dodgers and Arizona dbacks are scheduled to meet in MLB action at Dodger Stadium on Wednesday, starting at 10:10PM ET.

Dustin May (1-4, 4.43 ERA) will start for the Dodgers, while the Diamondbacks will counter with Corbin Burnes (3-1, 2.56 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Dodgers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Arizona-LA Dodgers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Dodgers' chance of winning at 56%, with the Diamondbacks at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Dodgers predictions page.

Dodgers vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Diamondbacks and Dodgers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Dodgers a 56% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 62% chance of covering the run line, while the 9-run over/under has a 51% chance of staying under.

Diamondbacks vs. Dodgers Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	Dodgers
Run Line	+1.5 (-162)	-1.5 (+140)
Moneyline	+130	-144
Total	o9 (-120)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Dodgers Picks and Best Bets

Our model's strongest edge in today's Diamondbacks vs. Dodgers matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. Dodgers Game-Day Updates and Essential Details

Wednesday's MLB game between the Dodgers and Diamondbacks at Dodger Stadium is scheduled to commence at 10:10PM ET.

• Who: Arizona Diamondbacks vs. Los Angeles Dodgers
• Date: Wednesday, May 21, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: Dodger Stadium

Dimers.com's comprehensive preview of Wednesday's Diamondbacks vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. LA Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Dodgers, with a 56% win probability, will likely beat the Diamondbacks on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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