Diamondbacks vs. White Sox Prediction: Arizona Predicted to Win Wednesday's MLB Matchup [6/25/2025]

The Chicago White Sox will square off with the Arizona Diamondbacks in MLB action at Rate Field on Wednesday, beginning at 2:10PM ET.

The White Sox will have Sean Burke (3-7, 4.50 ERA) as their starting pitcher, while the Diamondbacks have opted for Zac Gallen (5-8, 5.60 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Diamondbacks-White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 58%, with the White Sox at 42%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. White Sox predictions page.

White Sox vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Diamondbacks and White Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 58% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 55% chance of covering the run line, while the over/under total of 8 runs has an equal 50-50 chance of hitting.

Diamondbacks vs. White Sox Odds [6/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	White Sox
Run Line	-1.5 (+112)	+1.5 (-134)
Moneyline	-150	+128
Total	o8 (-114)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Diamondbacks vs. White Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Diamondbacks vs. White Sox Game-Day Updates and Essential Details

Wednesday's MLB matchup between the White Sox and Diamondbacks at Rate Field is scheduled to start at 2:10PM ET.

• Who: Arizona Diamondbacks vs. Chicago White Sox
• Date: Wednesday, June 25, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Wednesday's Diamondbacks vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 58% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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