Diamondbacks vs. White Sox Prediction: Arizona Predicted to Win Monday's MLB Matchup [6/23/2025]

The Chicago White Sox and Arizona dbacks will lock horns in MLB action at Rate Field on Monday, starting at 7:40PM ET.

The White Sox will have Shane Smith (3-4, 2.85 ERA) as their starting pitcher, up against Eduardo Rodriguez (2-4, 5.93 ERA) for the Diamondbacks.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Diamondbacks-White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Diamondbacks are likely to win, with a probability of 57%, compared to the White Sox' 43%."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. White Sox predictions page.

White Sox vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Monday's MLB matchup between the Diamondbacks and White Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Diamondbacks a 57% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the 9.5-run over/under has a 57% chance of staying under.

Diamondbacks vs. White Sox Odds [6/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Diamondbacks	White Sox
Run Line	-1.5 (+123)	+1.5 (-137)
Moneyline	-142	+120
Total	o9.5 (-104)	u9.5 (-117)

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Diamondbacks vs. White Sox matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Diamondbacks vs. White Sox Game-Day Updates and Essential Details

Monday's MLB game between the White Sox and Diamondbacks at Rate Field is scheduled to begin at 7:40PM ET.

• Who: Arizona Diamondbacks vs. Chicago White Sox
• Date: Monday, June 23, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's in-depth preview of Monday's Diamondbacks vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Diamondbacks vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Diamondbacks, with a 57% win probability, will likely beat the White Sox on Monday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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