Arizona Cardinals vs. San Francisco 49ers updated prediction featuring James Conner, Christian McCaffrey [Week 3, 2025]

Dimers' latest NFL predictions are live for San Francisco 49ers and Arizona Cardinals in Week 3, with our model giving the 49ers a 60% of winning against the Cardinals on Sunday.

This update builds on our early 49ers-Cardinals predictions, delivering recalculated win probabilities, score projections, and TD predictions for James Conner, Christian McCaffrey, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Cardinals vs. 49ers page.

What's changed? Arizona vs. San Francisco updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Cardinals vs. Niners matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Cardinals 40%, 49ers 60%
• Predicted Final Score: Cardinals 21-23 49ers
• Spread: Cardinals (+2.5) 50%, 49ers (-2.5) 50%
• Total Points (45.5): Over 47%, Under 53%

As of September 18, 2025, these Cardinals-49ers figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Cardinals-Niners on Sunday:

Arizona Cardinals

• James Conner: 49.5% probability
• Marvin Harrison: 34.2% probability
• Trey McBride: 30.8% probability

San Francisco 49ers

• Christian McCaffrey: 61.0% probability
• Jauan Jennings: 31.4% probability
• Ricky Pearsall: 29.8% probability

Cardinals vs. Niners latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Cardinals +2.5 (-105), 49ers -2.5 (-115)
• Moneyline: Cardinals +140, 49ers -142
• Total: Over/Under 45.5 (-110/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Cardinals vs. Niners Week 3 details

The NFL Week 3 matchup between the 49ers and Cardinals at Levi's Stadium is scheduled for September 21, 2025.

• Who: Arizona Cardinals vs. San Francisco 49ers
• Date: Sunday, September 21, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Levi's Stadium

NFL Week 3 betting promos and codes

Make the most of Dimers' Cardinals vs. 49ers predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the 49ers, with a 60% win probability, will likely beat the Cardinals in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.