Cardinals vs. 49ers prediction: San Francisco favored to win in NFL Week 3, 2025

The San Francisco 49ers will square off with the Arizona Cardinals in NFL Week 3 action at Levi's Stadium on Sunday, beginning at 4:25PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-49ers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 56%, while the Cardinals have 44%."

This gameday Cardinals vs. 49ers betting preview builds on my Cardinals vs. 49ers prediction that was published earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Cardinals vs. 49ers predictions page.

Cardinals vs. 49ers Predictions

Since our Cardinals-49ers predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Cardinals and 49ers 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the 49ers a 56% chance of defeating the Cardinals in Week 3 of the NFL season. Our predicted final score has the 49ers winning 23-21.

According to our model, the bookies have got it right, and the Cardinals and 49ers each have a 50% chance of covering the spread, while the over/under total of 44.5 points also has an equal 50-50 chance of hitting.

Cardinals vs. 49ers odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Cardinals	49ers
Spread	+1.5 (-110)	-1.5 (-108)
Moneyline	+105	-122
Total	o44.5 (-108)	u44.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. 49ers picks and best bets

Our model's strongest edge in today's Cardinals vs. 49ers matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Cardinals vs. 49ers TD scorers

Who will score an anytime touchdown in Cardinals vs. 49ers?

According to our model, San Francisco's Christian McCaffrey is most likely to score the first touchdown in Cardinals vs. 49ers.

Our projections give McCaffrey a 17.4% chance of scoring the first TD at Levi's Stadium, while the 49ers running back is a 57.2% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Arizona Cardinals

Player	First TD Probability
James Conner (RB)	12.2%
Marvin Harrison (WR)	7.8%
Trey McBride (TE)	6.5%

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	17.4%
Ricky Pearsall (WR)	7.2%
Brian Robinson (RB)	4.4%

Anytime touchdown scorer predictions

Arizona Cardinals

Player	Anytime TD Probability
James Conner (RB)	45.8%
Marvin Harrison (WR)	32.6%
Trey McBride (TE)	28.1%

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	57.2%
Ricky Pearsall (WR)	29.5%
Brian Robinson (RB)	19.4%

Cardinals vs 49ers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Cardinals-49ers page now to access every player prop projection.

Cardinals vs. 49ers quarterbacks

Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for fewer yards than the 49ers' Mac Jones.

Cardinals rushing

James Conner, Kyler Murray and Trey Benson are projected to be the leading rushers for the Cardinals.

Player	Position
James Conner	RB
Kyler Murray	QB
Trey Benson	RB

49ers rushing

Christian McCaffrey, Brian Robinson and Mac Jones are expected to lead the 49ers in rushing yards.

Player	Position
Christian McCaffrey	RB
Brian Robinson	RB
Mac Jones	QB

Cardinals receiving

Trey McBride, Marvin Harrison, Michael Wilson, James Conner and Trey Benson are projected to top the receiving yards for the Cardinals.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
James Conner	RB
Trey Benson	RB

49ers receiving

Ricky Pearsall, Christian McCaffrey, Kendrick Bourne, Jake Tonges and Marquez Valdes-Scantling are projected to lead the 49ers in receiving yards.

Player	Position
Ricky Pearsall	WR
Christian McCaffrey	RB
Kendrick Bourne	WR
Jake Tonges	TE
Marquez Valdes-Scantling	WR

Cardinals vs. Niners game-day updates and essential details

The NFL Week 3 matchup between the 49ers and Cardinals at Levi's Stadium is scheduled to begin at 4:25PM ET.

• Who: Arizona Cardinals vs. San Francisco 49ers
• Date: Sunday, September 21, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Levi's Stadium

Dimers' in-depth preview of Sunday's Cardinals vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Niners picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the 49ers, with a 56% win probability, will likely beat the Cardinals in Week 3 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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