Arizona Cardinals vs. New Orleans Saints updated prediction featuring James Conner, Alvin Kamara [Week 1, 2025]

Dimers' latest NFL predictions are live for New Orleans Saints and Arizona Cardinals in Week 1, with our model giving the Cardinals a 73% of winning against the Saints on Sunday.

This update builds on our early Saints-Cardinals predictions, providing refreshed win probabilities, score projections, and TD predictions for James Conner, Alvin Kamara, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Cardinals vs. Saints page.

What's changed? Arizona vs. New Orleans updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Cardinals vs. Saints matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Cardinals 73%, Saints 27%
• Predicted Final Score: Cardinals 24-18 Saints
• Spread: Cardinals (-6.5) 43%, Saints (+6.5) 57%
• Total Points (43.5): Over 48%, Under 52%

As of September 5, 2025, these Cardinals-Saints calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Cardinals-Saints on Sunday:

Arizona Cardinals

• James Conner: 52.1% probability
• Marvin Harrison: 34.2% probability
• Trey McBride: 28.1% probability

New Orleans Saints

• Alvin Kamara: 45.2% probability
• Chris Olave: 26.0% probability
• Rashid Shaheed: 23.0% probability

Cardinals vs. Saints latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Cardinals -6.5 (-104), Saints +6.5 (-110)
• Moneyline: Cardinals -270, Saints +240
• Total: Over/Under 43.5 (-108/-112)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Cardinals vs. Saints Week 1 details

The NFL Week 1 matchup between the Saints and Cardinals at Caesars Superdome is scheduled for September 7, 2025.

• Who: Arizona Cardinals vs. New Orleans Saints
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

NFL Week 1 betting promos and codes

Make the most of Dimers' Cardinals vs. Saints predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $300 in Bonus Bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in Bonus Bets win or lose.

Conclusion

We predict the Cardinals, with a 73% win probability, will likely beat the Saints in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Saints matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.