Cardinals vs. Saints prediction: Arizona favored to win in NFL Week 1, 2025

The New Orleans Saints will take on the favored Arizona Cardinals in NFL Week 1 action at Caesars Superdome on Sunday, commencing at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model projects the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Saints game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 72%, while the Saints have 28%."

This updated Cardinals vs. Saints betting preview builds on my Cardinals vs. Saints prediction that was released earlier in the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive Cardinals vs. Saints predictions page.

Cardinals vs. Saints Predictions

Since our Cardinals-Saints predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Cardinals and Saints 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Cardinals a 72% chance of defeating the Saints in Week 1 of the NFL season. Our predicted final score has the Cardinals winning 25-19.

According to our model, the Saints (+6) have a 53% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.

Cardinals vs. Saints odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Cardinals	Saints
Spread	-6 (-125)	+6 (-105)
Moneyline	-250	+240
Total	o44.5 (-108)	u44.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Saints picks and best bets

Our model's strongest edge in today's Cardinals vs. Saints matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season, with today's best NFL bets populating now.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Cardinals vs. Saints TD scorers

Who will score the first touchdown in Cardinals vs. Saints?

According to our list of touchdown scorer predictions for Week 1, Arizona's James Conner is most likely to score the first touchdown in Cardinals vs. Saints.

Our projections give Conner a 16.7% chance of scoring the first TD at Caesars Superdome, while the Cardinals running back is a 52.3% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Arizona Cardinals

Player	First TD Probability
James Conner (RB)	16.7%
Marvin Harrison (WR)	9.0%
Trey McBride (TE)	7.3%

New Orleans Saints

Player	First TD Probability
Alvin Kamara (RB)	13.5%
Chris Olave (WR)	6.6%
Rashid Shaheed (WR)	5.7%

Anytime touchdown scorer predictions

Arizona Cardinals

Player	Anytime TD Probability
James Conner (RB)	52.3%
Marvin Harrison (WR)	33.0%
Trey McBride (TE)	27.7%

New Orleans Saints

Player	Anytime TD Probability
Alvin Kamara (RB)	45.8%
Chris Olave (WR)	25.8%
Rashid Shaheed (WR)	22.9%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 1 touchdown scorer predictions

Cardinals vs Saints player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Saints. For more, check out today's highest-probability NFL prop bets.

Already a Dimers Pro member? Head to our Cardinals-Saints page now to access every player prop projection.

Cardinals vs. Saints quarterbacks

Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for more yards than the Saints' Spencer Rattler.

Cardinals rushing

James Conner, Kyler Murray and Trey Benson are projected to be the leading rushers for the Cardinals.

Player	Position
James Conner	RB
Kyler Murray	QB
Trey Benson	RB

Saints rushing

Alvin Kamara, Spencer Rattler and Kendre Miller are expected to lead the Saints in rushing yards.

Player	Position
Alvin Kamara	RB
Spencer Rattler	QB
Kendre Miller	RB

Cardinals receiving

Trey McBride, Marvin Harrison, Michael Wilson, Zay Jones and James Conner are projected to top the receiving yards for the Cardinals.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
Zay Jones	WR
James Conner	RB

Saints receiving

Chris Olave, Rashid Shaheed, Alvin Kamara, Juwan Johnson and Brandin Cooks are projected to lead the Saints in receiving yards.

Player	Position
Chris Olave	WR
Rashid Shaheed	WR
Alvin Kamara	RB
Juwan Johnson	TE
Brandin Cooks	WR

Cardinals vs. Saints game-day updates and essential details

The NFL Week 1 game between the Saints and Cardinals at Caesars Superdome is scheduled to commence at 1:00PM ET.

• Who: Arizona Cardinals vs. New Orleans Saints
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

Dimers.com's comprehensive preview of this week's Cardinals vs. Saints matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Saints picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 72% win probability, will likely beat the Saints in Week 1 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Saints insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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