Arizona Cardinals vs. New Orleans Saints early prediction: Expert picks for NFL Week 1, 2025

The Arizona Cardinals and New Orleans Saints will meet in Week 1 of the NFL season at Caesars Superdome on Sunday, September 7, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cardinals vs. Saints predictions page.

Arizona vs. New Orleans early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cardinals vs. Saints game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cardinals 70%, Saints 30%
• Predicted final score: Cardinals 23-18 Saints
• Spread: Cardinals (-6.5) 46%, Saints (+6.5) 54%
• Total points (42.5): Over 50%, Under 50%

As of August 31, 2025, these Cardinals-Saints figures and predictions reflect the latest data and insights available.

Cardinals vs. Saints Week 1 details

The NFL Week 1 matchup between the Saints and Cardinals at Caesars Superdome is scheduled for September 7, 2025.

• Who: Arizona Cardinals vs. New Orleans Saints
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

Cardinals vs. Saints opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Cardinals -6.5 (-110), Saints +6.5 (-110)
• Moneyline: Cardinals -270, Saints +240
• Total: Over/Under 42.5 (-105/-112)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cardinals, with a 70% win probability, will likely beat the Saints in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Saints matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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