App State vs. Southern Miss prediction: Appalachian State favored to win in college football Week 3, 2025

Southern Miss and Appalachian State will meet in Week 3 college football action at M.M. Roberts Stadium on Saturday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Appalachian State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive App State vs. Southern Miss predictions page.

App State vs. Southern Miss prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of App State vs. Southern Miss 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Appalachian State a 56% chance of beating Southern Miss. Our predicted final score has Appalachian State winning 27-25.

According to our model, Southern Miss (+3.5) has a 54% chance of covering the spread, while the 55.5-point over/under has a 56% chance of going over.

App State vs. Southern Miss odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	App State	Southern Miss
Spread	-3.5 (-105)	+3.5 (-114)
Moneyline	-150	+136
Total	o55.5 (-110)	u55.5 (-108)

All odds are correct at the time of publication and are subject to change.

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App State vs. Southern Miss picks and best bets

Our model's biggest edge in today's App State vs. Southern Miss matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

App State vs. Southern Miss game-day updates and essential details

Saturday's college football action between Southern Miss and App State at M.M. Roberts Stadium is scheduled to commence at 7:00PM ET.

• Who: Appalachian State vs. Southern Miss
• Date: Saturday, September 13, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: M.M. Roberts Stadium

Dimers' in-depth preview of Saturday's App State vs. Southern Miss matchup includes our prediction, picks and the latest betting odds.

Before making any App State vs. Southern Miss picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Appalachian State, with a 56% win probability, will likely beat Southern Miss on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Appalachian State vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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