49ers vs. Steelers Week 1 Prediction and Odds - September 10, 2023

The Pittsburgh Steelers will face the San Francisco 49ers in NFL Week 1 action at Acrisure Stadium on Sunday, beginning at 1:00PM ET.

Dimers' top betting picks for 49ers vs. Steelers, as well as game predictions, betting odds and projected player stats, are featured below.

This San Francisco vs. Pittsburgh betting preview is proudly sponsored by Bet365, which has a great Bet $1, Get $365 in Bonus Bets offer for new customers.

Who Will Win: 49ers vs. Steelers

Based on state-of-the-art machine learning and data, Dimers.com has simulated Sunday's 49ers-Steelers NFL matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the 49ers a 61% chance of defeating the Steelers in Week 1 of the NFL season.

More: Betting Predictions for 49ers vs. Steelers

49ers vs. Steelers Odds

• Spread: Steelers +1.5 (-110), 49ers -1.5 (-105)
• Moneyline: Steelers +105, 49ers -118
• Total: Over/Under 41.5 (-110/-110)

The Steelers are +1.5 underdogs versus the 49ers, with -110 at PointsBet the best odds currently available.

For the favored 49ers (-1.5) to cover the spread, BetMGM has the best odds currently on offer at -105.

PointsBet currently has the best moneyline odds for the Steelers at +105. That means you can throw down $100 to profit $105, earning a total payout of $205, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the 49ers at -118, where you can risk $118 to win $100, for a total payout of $218, if they come out on top.

The Over/Under for total points scored is set at 41.5 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-1.5) have a 52% chance of covering the spread, while the Over/Under total of 41.5 points has an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets: 49ers vs. Steelers

• Spread: 49ers -1.5 @ -105 via BetMGM (52% probability)
• Moneyline: 49ers @ -118 via FanDuel Sportsbook (61% probability) 🔥
• Total: Under 41.5 @ -110 via PointsBet (50% probability)

Any time you see a 🔥, that means you've found one of Dimers' best bets today across all major pro and college sports.

Dimers' best bets are based on complex modeling and betting expertise to help you make better decisions with the legal sportsbooks in your state.

49ers vs. Steelers Prediction

Dimers.com's predicted final score for San Francisco vs. Pittsburgh at Acrisure Stadium in Week 1 has the 49ers winning 22-19.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of this week's 49ers-Steelers game in Week 1, including pregame predictions, best betting picks, and live win probabilities.

49ers vs. Steelers Player Props

Who will score an anytime touchdown in 49ers vs. Steelers? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Steelers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop bets for Sunday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first touchdown in 49ers vs. Steelers.

DimersBOT gives McCaffrey a 13.8% chance of scoring the first TD at Acrisure Stadium, while the 49ers RB is a 50.4% chance of reaching the end zone at any point in the game.

Scroll down for our complete list of first and anytime TD scorer probabilities, which provide a great avenue for you to use this DraftKings Sportsbook offer, which unlocks $200 in bonus bets from a $5 bet on any of the below players.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 13.8% probability
• Deebo Samuel: 8.7% probability
• Brandon Aiyuk: 8.2% probability
• Elijah Mitchell: 6.5% probability
• George Kittle: 6.1% probability

Pittsburgh Steelers

• Najee Harris: 10.0% probability
• George Pickens: 6.9% probability
• Pat Freiermuth: 5.7% probability
• Diontae Johnson: 5.7% probability
• Jaylen Warren: 5.2% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 50.4% probability
• Deebo Samuel: 33.7% probability
• Brandon Aiyuk: 32.7% probability
• Elijah Mitchell: 26.8% probability
• George Kittle: 25.5% probability

Pittsburgh Steelers

• Najee Harris: 40.1% probability
• George Pickens: 28.4% probability
• Pat Freiermuth: 24.4% probability
• Diontae Johnson: 24.4% probability
• Jaylen Warren: 22.4% probability

49ers-Steelers Projected Player Stats

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 238 passing yards. The Steelers' Kenny Pickett is expected to throw for 194 yards.

49ers Starting QB

• Brock Purdy: 238 projected yards

Steelers Starting QB

• Kenny Pickett: 194 projected yards

49ers Rushing

• Christian McCaffrey: 66 projected yards
• Elijah Mitchell: 40 projected yards
• Jordan Mason: 18 projected yards

Steelers Rushing

• Najee Harris: 62 projected yards
• Jaylen Warren: 28 projected yards
• Kenny Pickett: 19 projected yards

49ers Receiving

• Brandon Aiyuk: 57 projected yards
• Deebo Samuel: 53 projected yards
• George Kittle: 47 projected yards
• Christian McCaffrey: 35 projected yards
• Jauan Jennings: 20 projected yards

Steelers Receiving

• Diontae Johnson: 55 projected yards
• George Pickens: 52 projected yards
• Pat Freiermuth: 41 projected yards
• Allen Robinson: 24 projected yards
• Calvin Austin: 19 projected yards

Don't forget, DimersBOT updates frequently, so keep checking this article for the latest betting analysis before 49ers vs. Steelers on Sunday September 10, 2023.

49ers vs. Steelers 2023

The NFL Week 1 action between the Steelers and 49ers at Acrisure Stadium is scheduled to begin at 1:00PM ET.

• Who: San Francisco 49ers vs. Pittsburgh Steelers
• Date: Sunday September 10, 2023
• Time: 1:00PM ET / 10:00AM PT
• Venue: Acrisure Stadium

Looking to join an online sportsbook and start betting on the NFL? We've reviewed the best available welcome offers in every legal betting state.

Make Smarter Sports Betting Decisions Today

Dimers' predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While our 49ers vs. Steelers predictions can help you make informed decisions, it's crucial that you only bet what you can afford to lose and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What NFL Games Are on Today?

The 49ers and Steelers aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single NFL game via our NFL predictions. Not only do we provide with you quality predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!

In addition to our leading NFL predictions, Dimers also offers the best NFL prop bets today, projecting passing yards, touchdowns, and more against the top odds available every single day of the NFL season.