NFL- More Betting
49ers vs. Seahawks Predictions and Odds - Dec 5, 2021

The Seattle Seahawks square off with the San Francisco 49ers in NFL Week 13 action at Lumen Field on Sunday, starting at 4:25 PM EST.
Dimers' top betting picks for 49ers vs. Seahawks, as well as game predictions, best odds and player props, are featured in this article.
Who will win 49ers vs. Seahawks?
Using high-tech computer power and data, Dimers.com has simulated Sunday's 49ers-Seahawks NFL matchup 10,000 times.
Dimers' revolutionary predictive analytics model, DimersBOT, gives the 49ers a 65% chance of beating the Seahawks.
MORE: 49ers vs. Seahawks Simulated 10,000 Times
Point Spread, Moneyline and Over/Under
The Seahawks are +2.5 underdogs against the 49ers, with -110 at Caesars Sportsbook the best odds available.
For the favored 49ers (-2.5) to cover the spread, Caesars Sportsbook also has the best odds on offer at -110.
BetMGM has the best moneyline odds for the Seahawks at +125. That means you can bet $100 to profit $125, earning a total payout of $225, if they win.
Meanwhile, DraftKings Sportsbook has the best moneyline odds for the 49ers at -140, where you can risk $140 to win $100, for a total payout of $240, if they come out on top.
The Over/Under for total points scored is set at 44.5 with BetMGM, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -108.
As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.
According to DimersBOT, the 49ers (-2.5) are a 61% chance of covering the spread, while the 44.5-point Over/Under is considered an equal 50-50 chance of hitting.
MORE: Predictions for Every NFL Week 13 Matchup
Best Bets for 49ers vs. Seahawks
- Spread: 49ers -2.5 at -110 with Caesars Sportsbook (61% probability) 🔥
- Moneyline: 49ers Win at -140 with DraftKings Sportsbook (65% probability) 🔥
- Over/Under: Under 44.5 at -108 with FanDuel Sportsbook (50% probability)
Any time you see a 🔥, that means it's one of Dimers' best bets today across all sports.
49ers vs. Seahawks Score Prediction
Dimers.com's predicted final score for San Francisco vs. Seattle at Lumen Field on Sunday has the 49ers winning 24-20.
Use our dynamic widget below to view the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.
Dimers has full betting coverage of this week's 49ers-Seahawks matchup, including pre-game predictions, computer picks, and live updates.
49ers vs. Seahawks Player Props
Who will score an anytime touchdown in 49ers vs. Seahawks? The data is in.
Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Seahawks, as well as projected player stats.
And you know what, we provide this information to you for FREE to help you select the best prop bets for Sunday's game.
According to DimersBOT, San Francisco's Elijah Mitchell is most likely to score the first TD in 49ers vs. Seahawks.
DimersBOT gives Mitchell a 15.0% chance of getting in for six first at Lumen Field, while the 49ers RB is a 53.9% chance of scoring an anytime touchdown.
First Touchdown Scorer Probabilities
San Francisco 49ers
- Elijah Mitchell: 15.0% probability
- Brandon Aiyuk: 8.7% probability
- George Kittle: 7.2% probability
- Jeff Wilson: 6.3% probability
- Jauan Jennings: 3.6% probability
Seattle Seahawks
- D.K. Metcalf: 9.1% probability
- Tyler Lockett: 8.4% probability
- Alex Collins: 8.1% probability
- Gerald Everett: 3.7% probability
- Freddie Swain: 2.9% probability
Anytime Touchdown Scorer Probabilities
San Francisco 49ers
- Elijah Mitchell: 53.9% probability
- Brandon Aiyuk: 37.6% probability
- George Kittle: 31.7% probability
- Jeff Wilson: 26.5% probability
- Jauan Jennings: 17.5% probability
Seattle Seahawks
- D.K. Metcalf: 38.7% probability
- Alex Collins: 35.4% probability
- Tyler Lockett: 34.3% probability
- Gerald Everett: 19.0% probability
- Freddie Swain: 14.7% probability
Projected Box Score
Of the starting quarterbacks, the 49ers' Jimmy Garoppolo is projected for 221 passing yards and 1.4 passing touchdowns, while the Seahawks' Russell Wilson is expected to throw for 220 yards and 1.7 TDs.
49ers Starting QB
- Jimmy Garoppolo: 221 Passing Yards, 1.4 Passing TDs
Seahawks Starting QB
- Russell Wilson: 220 Passing Yards, 1.7 Passing TDs
49ers Rushing
- Elijah Mitchell: 83 Rushing Yards, 0.7 TDs
- Jeff Wilson: 26 Rushing Yards, 0.2 TDs
- Jimmy Garoppolo: 9 Rushing Yards, 0.1 TDs
Seahawks Rushing
- Alex Collins: 47 Rushing Yards, 0.4 TDs
- Russell Wilson: 21 Rushing Yards, 0.1 TDs
- DeeJay Dallas: 13 Rushing Yards, 0.1 TDs
49ers Receiving
- Brandon Aiyuk: 65 Receiving Yards, 0.4 TDs
- George Kittle: 56 Receiving Yards, 0.4 TDs
- Jauan Jennings: 28 Receiving Yards, 0.2 TDs
- Trent Sherfield: 22 Receiving Yards, 0.1 TDs
- Mohamed Sanu: 19 Receiving Yards, 0.1 TDs
Seahawks Receiving
- Tyler Lockett: 69 Receiving Yards, 0.4 TDs
- D.K. Metcalf: 64 Receiving Yards, 0.4 TDs
- Gerald Everett: 24 Receiving Yards, 0.2 TDs
- Freddie Swain: 22 Receiving Yards, 0.1 TDs
- Will Dissly: 14 Receiving Yards, 0.1 TDs
Remember, DimersBOT updates frequently, so keep an eye on this page for the latest betting insights ahead of 49ers vs. Seahawks on Sunday December 5, 2021.
49ers vs. Seahawks 2021 Game Info
When do the Seahawks play the 49ers?
- Date: Sunday December 5, 2021
- Time: 4:25 PM EST / 1:25 PM PST
- Venue: Lumen Field
Enjoy Dimers and want to keep the site free? Every time you join a sportsbook featured here, we get paid a small fee.
These fees help us keep Dimers free for everyone. So, if you like what you see, support us by joining one of our featured sports betting partners.
Want more NFL analysis like this?
So, you liked our 49ers vs. Seahawks betting analysis? Awesome. Did you know our NFL Betting News page has a comprehensive betting preview for every NFL matchup the second the sportsbooks put out their odds?
That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to produce the most reliable NFL betting previews and get the jump on the public and the sportsbooks.
It's only a click away, so why not see for yourself?