49ers vs. Rams Predictions and Odds - Jan 9, 2022

The Los Angeles Rams square off with the San Francisco 49ers in NFL Week 18 action at SoFi Stadium on Sunday, beginning at 4:25PM EST.

Dimers' free betting picks for 49ers vs. Rams, as well as our score prediction and best odds, are featured below.

Who will win 49ers vs. Rams?

Using cutting-edge machine learning and data, Dimers.com has simulated Sunday's 49ers-Rams NFL game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Rams a 61% chance of defeating the 49ers.

MORE: 49ers vs. Rams Simulated 10K Times

Point Spread, Moneyline and Over/Under

The Rams are -3.5 favorites against the 49ers, with -105 at Caesars Sportsbook the best odds available.

For the underdog 49ers (+3.5) to cover the spread, BetMGM has the best odds on the market at -110.

FanDuel Sportsbook has the best moneyline odds for the Rams at -198. That means you can risk $198 to win $100, for a total payout of $298, if they get the W.

Elsewhere, BetMGM has the best moneyline odds for the 49ers at +155, where you can bet $100 to profit $155, earning a total payout of $255, if they win.

The Over/Under for total points scored sits at 45.5 with Caesars Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (+3.5) are a 52% chance of covering the spread, while the Over/Under total of 45.5 points is a 52% chance of going Over.

MORE: Super Bowl 56 Probabilities and Odds

Best Bets for 49ers vs. Rams

• Spread: 49ers +3.5 at -110 with BetMGM (52% probability)
• Moneyline: Rams Win at -198 with FanDuel Sportsbook (61% probability)
• Over/Under: Over 45.5 at -110 with Caesars Sportsbook (52% probability)

49ers vs. Rams Score Prediction

Dimers.com's predicted final score for San Francisco vs. LA Rams at SoFi Stadium on Sunday has the Rams winning 24-21.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's 49ers-Rams matchup, including pre-game predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this page for the latest betting analysis before 49ers vs. Rams on Sunday January 9, 2022.

Bet $10, Win $200 if 49ers or Rams Score a TD

BetMGM, the king of sportsbooks, is offering new users the opportunity to Bet $10, Win $200 if the 49ers or Rams score a touchdown on Sunday.

That's right – bet 10 bucks and get 200 bucks in Free Bets if either team finds the end zone. It's that simple.

To take advantage of this offer, join BetMGM via this exclusive link, deposit $10+ and place, as your first real-money bet after opening your account, a single $10 pre-game, moneyline wager on San Francisco vs. LA Rams.

If either team scores a TD, you'll receive $200 in Free Bets from BetMGM. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

49ers vs. Rams 2022 Game Info

When do the Rams play the 49ers?

• Date: Sunday January 9, 2022
• Time: 4:25PM EST / 1:25PM PST
• Venue: SoFi Stadium

Ready to join an online sportsbook and start betting on the NFL today? We've got access to the best available sign-up offers in every legal betting state.

What other NFL games are on today?

Now you've got the 411 on 49ers vs. Rams, take a look at the latest betting coverage for all upcoming NFL games in Dimers' NFL Bet Hub. There you can find probabilities and odds, as well as our best bets for each and every NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!