49ers vs. Cowboys Predictions and Odds - Jan 16, 2022

NFL action continues on Sunday at 4:30PM EST as the San Francisco 49ers square off with the Dallas Cowboys in the Wild Card round of the 2021 NFL Playoffs at AT&T Stadium.

Dimers' top betting picks for 49ers vs. Cowboys, as well as game predictions, best odds and player props, are detailed below.

Today's San Francisco vs. Dallas betting analysis is proudly sponsored by FanDuel Sportsbook, which has an outstanding Bet $5, Win $150 promo for new users during this year's NFL Playoffs.

Who will win 49ers vs. Cowboys?

Using advanced computer power and data, Dimers.com has simulated Sunday's 49ers-Cowboys NFL game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the Cowboys a 59% chance of winning against the 49ers.

MORE: 49ers vs. Cowboys Simulated 10K Times

Point Spread, Moneyline and Over/Under

The Cowboys are -3.5 favorites against the 49ers, with -105 at DraftKings Sportsbook currently the best odds available.

For the underdog 49ers (+3.5) to cover the spread, bet365 currently has the best odds on the market at -110.

bet365 currently has the best moneyline odds for the Cowboys at -182, which means you can risk $182 to win $100, for a total payout of $282, if they get the W.

On the other hand, bet365 currently has the best moneyline odds for the 49ers at +160, where you can bet $100 to profit $160, earning a total payout of $260, if they win.

The Over/Under is set at 51 with bet365, which currently has the best odds for the Over at -110, while Caesars Sportsbook currently has the best odds for the Under at -105.

As always, check out all the sportsbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (+3.5) are a 57% chance of covering the spread, while the Over/Under total of 51 points is a 52% chance of going Over.

MORE: Best Bets Today for All Major Sports

Best Bets for 49ers vs. Cowboys

• Spread: 49ers +3.5 at -110 with bet365 (57% probability) 🔥
• Moneyline: 49ers Win at +160 with bet365 (3.9% edge)
• Over/Under: Over 51 at -110 with bet365 (52% probability)

If you see a 🔥, you know it's one of Dimers' best bets today across all major pro and college sports.

While the Cowboys are more likely to win the game, according to DimersBOT, taking the 49ers moneyline is the best option because of the 3.9% edge identified when comparing our data-led probabilities to the betting odds.

Taking advantage of the edges published here at Dimers.com is one of the keys to being profitable in the long run.

49ers vs. Cowboys Score Prediction

Dimers.com's predicted final score for San Francisco vs. Dallas at AT&T Stadium this Sunday has the Cowboys winning 27-24.

Use our dynamic widget below to see the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's 49ers-Cowboys matchup, including pre-game predictions, free picks, and live win probabilities.

49ers vs. Cowboys Player Props

Who will score the first touchdown in 49ers vs. Cowboys? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Cowboys, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you choose the best prop picks for Sunday's game.

According to DimersBOT, Dallas' Tony Pollard is most likely to score the first touchdown in 49ers vs. Cowboys.

DimersBOT gives Pollard a 2.0% chance of scoring the first TD at AT&T Stadium, while the Cowboys RB is a 4.0% chance of scoring an anytime touchdown.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Ross Dwelley: 2.0% probability
• Trey Lance: 2.0% probability
• Trent Sherfield: 2.0% probability
• Jauan Jennings: 2.0% probability
• Elijah Mitchell: 2.0% probability

Dallas Cowboys

• Tony Pollard: 2.0% probability
• Dak Prescott: 2.0% probability
• Noah Brown: 2.0% probability
• Ito Smith: 2.0% probability
• CeeDee Lamb: 2.0% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Ross Dwelley: 4.0% probability
• Trey Lance: 4.0% probability
• Trent Sherfield: 4.0% probability
• Jauan Jennings: 4.0% probability
• Elijah Mitchell: 4.0% probability

Dallas Cowboys

• Tony Pollard: 4.0% probability
• Dak Prescott: 4.0% probability
• Noah Brown: 4.0% probability
• Ito Smith: 4.0% probability
• CeeDee Lamb: 4.0% probability

Projected Box Score

Of the starting quarterbacks, the 49ers' Jimmy Garoppolo is projected for 246 passing yards and 1.7 passing touchdowns. The Cowboys' Dak Prescott is expected to throw for a whopping 269 yards and 1.8 TDs.

49ers Starting QB

• Jimmy Garoppolo: 246 Passing Yards, 1.7 Passing TDs

Cowboys Starting QB

• Dak Prescott: 269 Passing Yards, 1.8 Passing TDs

49ers Rushing

• Elijah Mitchell: 86 Rushing Yards, 0.5 TDs
• Deebo Samuel: 39 Rushing Yards, 0.4 TDs
• Jimmy Garoppolo: 9 Rushing Yards, 0.1 TDs

Cowboys Rushing

• Ezekiel Elliott: 60 Rushing Yards, 0.5 TDs
• Tony Pollard: 35 Rushing Yards, 0.3 TDs
• Dak Prescott: 16 Rushing Yards, 0.2 TDs

49ers Receiving

• Deebo Samuel: 86 Receiving Yards, 0.4 TDs
• George Kittle: 66 Receiving Yards, 0.3 TDs
• Brandon Aiyuk: 54 Receiving Yards, 0.3 TDs
• Jauan Jennings: 24 Receiving Yards, 0.2 TDs
• Elijah Mitchell: 14 Receiving Yards, 0.1 TDs

Cowboys Receiving

• CeeDee Lamb: 78 Receiving Yards, 0.5 TDs
• Amari Cooper: 63 Receiving Yards, 0.5 TDs
• Dalton Schultz: 47 Receiving Yards, 0.4 TDs
• Cedrick Wilson: 36 Receiving Yards, 0.2 TDs
• Tony Pollard: 18 Receiving Yards, 0.1 TDs

Don't forget, DimersBOT updates frequently, so check this article for any changes to our betting analysis before 49ers vs. Cowboys on Sunday January 16, 2022.

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49ers vs. Cowboys 2022 Game Info

When do the Cowboys play the 49ers?

• Date: Sunday January 16, 2022
• Time: 4:30PM EST / 1:30PM PST
• Venue: AT&T Stadium

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