49ers vs. Cardinals Week 11 Prediction and Odds - Nov 21, 2022

The Arizona Cardinals square off with the San Francisco 49ers in NFL Week 11 action at Estadio Azteca on Monday, starting at 8:15PM ET.

Dimers' top betting picks for 49ers vs. Cardinals, as well as game predictions, betting odds and projected player stats, are featured in this article.

Who will win 49ers vs. Cardinals?

Using high-tech machine learning and data, Dimers.com has simulated Monday's 49ers-Cardinals NFL game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the 49ers an 82% chance of defeating the Cardinals in Week 11 of the NFL season.

More: 49ers vs. Cardinals Simulated 10K Times

49ers vs. Cardinals Odds

• Spread: Cardinals +10 (-110), 49ers -10 (-105)
• Moneyline: Cardinals +345, 49ers -410
• Total: Over/Under 43 (-107/-107)

Point Spread, Moneyline and Over/Under

The Cardinals are currently +10 underdogs versus the 49ers, with -110 at PointsBet the best odds currently available.

For the favored 49ers (-10) to cover the spread, PointsBet also has the best odds currently on offer at -105.

Caesars Sportsbook currently has the best moneyline odds for the Cardinals at +345, which means you can bet $100 to profit $345, earning a total payout of $445, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -410, where you can risk $410 to win $100, for a total payout of $510, if they come out on top.

The Over/Under for total points scored sits at 43 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the Cardinals (+10) are a 51% chance of covering the spread, while the 43-point Over/Under is considered an equal 50-50 chance of hitting.

More: Best Prop Bets to Make Today

Best Bets for 49ers vs. Cardinals

• Spread: Cardinals +10 @ -110 via PointsBet (51% probability)
• Moneyline: 49ers @ -410 via DraftKings Sportsbook (82% probability)
• Total: Under 43 @ -107 via PointsBet (50% probability)

Dimers' best bets are based on complex simulations and wagering expertise to bring you the best possible plays 24/7/365.

49ers vs. Cardinals Prediction

Dimers.com's predicted final score for San Francisco vs. Arizona at Estadio Azteca in Week 11 has the 49ers winning 26-17.

Click or tap on See Matchup for more.

Dimers has full betting coverage of this week's 49ers-Cardinals matchup in Week 11, including pregame predictions, top betting picks, and live win probabilities.

49ers vs. Cardinals Player Props

Who will score an anytime touchdown in 49ers vs. Cardinals? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Cardinals, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Monday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first touchdown in 49ers vs. Cardinals.

DimersBOT gives McCaffrey a 13.8% chance of getting in for six first at Estadio Azteca, while the 49ers RB is a 50.3% chance of reaching the end zone at any point during the game.

Scroll down for our complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 13.8% probability
• Deebo Samuel: 9.8% probability
• Brandon Aiyuk: 7.8% probability
• Elijah Mitchell: 7.8% probability
• George Kittle: 7.7% probability

Arizona Cardinals

• James Conner: 10.2% probability
• DeAndre Hopkins: 8.5% probability
• Rondale Moore: 5.6% probability
• Trey McBride: 4.3% probability
• Keaontay Ingram: 2.1% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Christian McCaffrey: 50.3% probability
• Deebo Samuel: 38.0% probability
• Brandon Aiyuk: 33.2% probability
• Elijah Mitchell: 32.4% probability
• George Kittle: 31.5% probability

Arizona Cardinals

• James Conner: 42.7% probability
• DeAndre Hopkins: 37.2% probability
• Rondale Moore: 24.2% probability
• Trey McBride: 19.9% probability
• Keaontay Ingram: 10.3% probability

49ers-Cardinals Projected Player Stats

Of the starting quarterbacks, the 49ers' Jimmy Garoppolo is projected for 248 passing yards. The Cardinals' Colt McCoy is expected to throw for 218 yards.

49ers Starting QB

• Jimmy Garoppolo: 248 projected yards

Cardinals Starting QB

• Colt McCoy: 218 projected yards

49ers Rushing

• Christian McCaffrey: 60 projected yards
• Elijah Mitchell: 53 projected yards
• Deebo Samuel: 19 projected yards

Cardinals Rushing

• James Conner: 55 projected yards
• Colt McCoy: 14 projected yards
• Keaontay Ingram: 11 projected yards

49ers Receiving

• Brandon Aiyuk: 66 projected yards
• George Kittle: 54 projected yards
• Deebo Samuel: 46 projected yards
• Christian McCaffrey: 44 projected yards
• Jauan Jennings: 26 projected yards

Cardinals Receiving

• DeAndre Hopkins: 88 projected yards
• Rondale Moore: 62 projected yards
• Trey McBride: 35 projected yards
• James Conner: 27 projected yards
• Stephen Anderson: 19 projected yards

Don't forget, DimersBOT updates often, so refresh this page for any changes to our betting analysis before 49ers vs. Cardinals on Monday November 21, 2022.

49ers vs. Cardinals 2022

The NFL Week 11 action between the Cardinals and 49ers at Estadio Azteca is scheduled to begin at 8:15PM ET.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Monday November 21, 2022
• Time: 8:15PM ET / 5:15PM PT
• Venue: Estadio Azteca

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What other NFL games are on today?

Now you've got the 411 on 49ers vs. Cardinals, check out the latest betting predictions for all upcoming NFL games in Dimers' NFL Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!