49ers vs. Rams Preview and Prediction

49ers vs. Rams: Detailed Breakdown

Matchup Overview

• Teams: 49ers vs. Rams
• Date: Thursday, October 2, 2025
• Time: 8:15 PM ET
• Venue: SoFi Stadium
• NFL stats, rosters and injury reports

Current Betting Odds

• Spread: Rams favored at -2.5
• Total (Over/Under): 47.5
• Moneyline Odds: 49ers +110, Rams -120

Dimers' Win Probabilities

• 49ers: 46%
• Rams: 54%

Dimers.com's predictive NFL model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Projected Final Score

Our predicted final score for this NFL matchup is 49ers 23-24 Rams.

This prediction is based on each team's average score and player stats following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives the 49ers a win probability of 46%, while the Rams have a win probability of 54%.

Summary

The 49ers face off against the Rams in the NFL at SoFi Stadium on Thursday, October 2, 2025. On this page, you'll find our preview, analysis and data-driven projections for the game.

Our 49ers vs. Rams predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL picks, NFL props, NFL futures, NFL odds, and the latest NFL news.