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Virginia vs. Louisville Prediction, Picks and Odds

Our in-depth analysis offers a comprehensive prediction for the Virginia vs. Louisville NCAAF game on October 4, 2025. Drawing from 10,000 simulations, we provide expert picks, betting odds, and insights.

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Virginia
Predicted score
28
:
32
Oct 4, 7:30PM L&N Federal Credit Union Stadium
Louisville
Oct 4, 7:30PM L&N Federal Credit Union Stadium
Game PredictionsPre-Game
Dimers Pro Best Bets
Pre-Game Probabilities Last Updated: 4:45PM, Sep 29
Spread
Over / Under
Moneyline
Virginia
Virginia +7.0
Spread
57%
43%
Louisville
Virginia UVA
Virginia +7.0
Spread
57%
43%
Louisville LOU

Game Prediction Article

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Virginia vs. Louisville: Detailed Breakdown

Matchup Overview

  • Teams: Virginia vs. Louisville
  • Date: Saturday, October 4, 2025
  • Time: 3:30 PM ET
  • Venue: L&N Federal Credit Union Stadium

Current Betting Odds

  • Spread: Louisville favored at -7
  • Total (Over/Under): 62.5
  • Moneyline Odds: Virginia +230, Louisville -265

Dimers' Win Probabilities

  • Virginia: 39%
  • Louisville: 61%

Dimers.com's predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is Virginia 28-32 Louisville.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives Virginia a win probability of 39%, while Louisville has a win probability of 61%.

Summary

According to our analysis, Louisville is more likely to beat Virginia in CFB action at L&N Federal Credit Union Stadium on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Virginia vs. Louisville predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

Explore our expert college football predictions and the best college football bets today for more insights and betting opportunities.

Our in-depth analysis includes college football player props and college football futures, as well as constantly updated college football odds and the latest college football news.

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