Michigan State vs. Southern California Prediction, Picks and Odds

Michigan State vs. Southern California: Detailed Breakdown

Matchup Overview

• Teams: Michigan State vs. Southern California
• Date: Saturday, September 20, 2025
• Time: 11:00 PM ET
• Venue: Los Angeles Memorial Coliseum

Current Betting Odds

• Spread: Southern California favored at -19.5
• Total (Over/Under): 55.5
• Moneyline Odds: Michigan State +650, Southern California -909

Dimers' Win Probabilities

• Michigan State: 13%
• Southern California: 87%

Dimers.com's predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is Michigan State 19-38 Southern California.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives Michigan State a win probability of 13%, while Southern California has a win probability of 87%.

Summary

According to our analysis, Southern California is more likely to beat Michigan State in CFB action at Los Angeles Memorial Coliseum on Sunday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Michigan State vs. Southern California predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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