Southern Illinois vs. Southeast Missouri State Prediction, Picks and Odds

Southern Illinois vs. Southeast Missouri State: Detailed Breakdown

Matchup Overview

• Teams: Southern Illinois vs. Southeast Missouri State
• Date: Saturday, September 20, 2025
• Time: 7:00 PM ET
• Venue: Houck Field

Current Betting Odds

• Spread: Southern Illinois favored at -5.5
• Total (Over/Under): 54.5
• Moneyline Odds: Southern Illinois -205, Southeast Missouri State +195

Dimers' Win Probabilities

• Southern Illinois: 65%
• Southeast Missouri State: 35%

Dimers.com's predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is Southern Illinois 29-23 Southeast Missouri State.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives Southern Illinois a win probability of 65%, while Southeast Missouri State has a win probability of 35%.

Summary

According to our analysis, Southern Illinois is more likely to beat Southeast Missouri State in CFB action at Houck Field on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Southern Illinois vs. Southeast Missouri State predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

Explore our expert college football predictions and the best college football bets today for more insights and betting opportunities.

Our in-depth analysis includes college football player props and college football futures, as well as constantly updated college football odds and the latest college football news.